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• Daa Conference 2010 Programs

Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are estimated to be infected by HCV in Brazil representing a major public health issue. The aim of this paper was to review the epidemiology and management of chronic hepatitis C from a Brazilian perspective.

The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed. Introduction Hepatitis C virus (HCV) was first described as non-A, non-B hepatitis in the 1990s in patients who presented with acute hepatitis after transfusion of blood products []. HCV is an enveloped RNA virus with 10 protein coding genes and a member of the family Flaviviridae, which targets hepatocytes leading to liver damage []. Parenteral transmission due to intravenous drug use, followed by transfusion of blood products before HCV screening, has been described as the most frequent route of infection. However, HCV can also be transmitted sexually or vertically [].

Daa Conference 2010 Programs

74:2004-2005: Academic Senate. Table 1: AV 2010-2011. AV 2010-2011. International Conferences. National Conferences. Island Conferences. AV 2010-2011. DAA SPONSORED: 9 Departments/Programs. 3 Offices lnteruniversity Seminar on. Investigation in the Science of. Mathematics: Humacao, PR.